Main variables	No. of employees	Total
No. of companies carrying out R&D in Biotechnology	Fewer than 250 employees	1,040
No. of companies carrying out R&D in Biotechnology	250 or more employees	93
No. of companies carrying out R&D in Biotechnology	Total	1,133
%Companies according to biotechnology used: Genetic code	Fewer than 250 employees	32
%Companies according to biotechnology used: Genetic code	250 or more employees	43
%Companies according to biotechnology used: Genetic code	Total	33
%Companies according to biotechnology used: Functional units	Fewer than 250 employees	40
%Companies according to biotechnology used: Functional units	250 or more employees	51
%Companies according to biotechnology used: Functional units	Total	41
%Companies according to biotechnology used: Cellular and tissue culturing and engineering	Fewer than 250 employees	22
%Companies according to biotechnology used: Cellular and tissue culturing and engineering	250 or more employees	41
%Companies according to biotechnology used: Cellular and tissue culturing and engineering	Total	24
%Companies according to biotechnology used: Bioprocesses	Fewer than 250 employees	48
%Companies according to biotechnology used: Bioprocesses	250 or more employees	69
%Companies according to biotechnology used: Bioprocesses	Total	50
%Companies according to biotechnology used: Sub-cellular organisms	Fewer than 250 employees	5
%Companies according to biotechnology used: Sub-cellular organisms	250 or more employees	12
%Companies according to biotechnology used: Sub-cellular organisms	Total	6
%Companies according to biotechnology used: Bio-computing	Fewer than 250 employees	24
%Companies according to biotechnology used: Bio-computing	250 or more employees	28
%Companies according to biotechnology used: Bio-computing	Total	24
%Companies according to biotechnology used: Nanobiotechnology	Fewer than 250 employees	13
%Companies according to biotechnology used: Nanobiotechnology	250 or more employees	13
%Companies according to biotechnology used: Nanobiotechnology	Total	13
%Companies according to biotechnology used: Other	Fewer than 250 employees	15
%Companies according to biotechnology used: Other	250 or more employees	8
%Companies according to biotechnology used: Other	Total	14
Companies in which biotechnology activities are: Main and/or exclusive	Fewer than 250 employees	581
Companies in which biotechnology activities are: Main and/or exclusive	250 or more employees	22
Companies in which biotechnology activities are: Main and/or exclusive	Total	603
Companies in which biotechnology activities are: A secondary line of business	Fewer than 250 employees	155
Companies in which biotechnology activities are: A secondary line of business	250 or more employees	18
Companies in which biotechnology activities are: A secondary line of business	Total	173
Companies in which biotechnology activities are: A tool necessary for production	Fewer than 250 employees	305
Companies in which biotechnology activities are: A tool necessary for production	250 or more employees	53
Companies in which biotechnology activities are: A tool necessary for production	Total	357
%Company by field(s) of ultimate application of biotechnology use: Human Health	Fewer than 250 employees	45
%Company by field(s) of ultimate application of biotechnology use: Human Health	250 or more employees	49
%Company by field(s) of ultimate application of biotechnology use: Human Health	Total	45
%Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture	Fewer than 250 employees	19
%Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture	250 or more employees	3
%Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture	Total	18
%Company by field(s) of ultimate application of biotechnology use: Food products	Fewer than 250 employees	30
%Company by field(s) of ultimate application of biotechnology use: Food products	250 or more employees	39
%Company by field(s) of ultimate application of biotechnology use: Food products	Total	31
%Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production	Fewer than 250 employees	23
%Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production	250 or more employees	17
%Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production	Total	22
%Company by field(s) of ultimate application of biotechnology use: Environment	Fewer than 250 employees	13
%Company by field(s) of ultimate application of biotechnology use: Environment	250 or more employees	17
%Company by field(s) of ultimate application of biotechnology use: Environment	Total	14
%Company by field(s) of ultimate application of biotechnology use: Industry	Fewer than 250 employees	13
%Company by field(s) of ultimate application of biotechnology use: Industry	250 or more employees	9
%Company by field(s) of ultimate application of biotechnology use: Industry	Total	12
Personnel in R&D in biotechnology (no. of persons)	Fewer than 250 employees	8,124
Personnel in R&D in biotechnology (no. of persons)	250 or more employees	3,386
Personnel in R&D in biotechnology (no. of persons)	Total	11,510
Personnel in R&D in biotechnology (no. of persons): Researchers	Fewer than 250 employees	4,552
Personnel in R&D in biotechnology (no. of persons): Researchers	250 or more employees	1,650
Personnel in R&D in biotechnology (no. of persons): Researchers	Total	6,202
Personnel in R&D in biotechnology (no. of persons): Technicians and assistants	Fewer than 250 employees	3,572
Personnel in R&D in biotechnology (no. of persons): Technicians and assistants	250 or more employees	1,736
Personnel in R&D in biotechnology (no. of persons): Technicians and assistants	Total	5,308
Personnel in R&D in biotechnology (no. of persons): women	Fewer than 250 employees	4,363
Personnel in R&D in biotechnology (no. of persons): women	250 or more employees	2,026
Personnel in R&D in biotechnology (no. of persons): women	Total	6,389
Personnel in R&D in biotechnology (no. of persons): (women) Researchers	Fewer than 250 employees	2,368
Personnel in R&D in biotechnology (no. of persons): (women) Researchers	250 or more employees	935
Personnel in R&D in biotechnology (no. of persons): (women) Researchers	Total	3,304
Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants	Fewer than 250 employees	1,995
Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants	250 or more employees	1,090
Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants	Total	3,086
Personnel in R&D in biotechnology (FTE)	Fewer than 250 employees	5,788.1
Personnel in R&D in biotechnology (FTE)	250 or more employees	2,448.9
Personnel in R&D in biotechnology (FTE)	Total	8,236.9
Personnel in R&D in biotechnology (FTE): Researchers	Fewer than 250 employees	3,364.3
Personnel in R&D in biotechnology (FTE): Researchers	250 or more employees	1,231.9
Personnel in R&D in biotechnology (FTE): Researchers	Total	4,596.1
Personnel in R&D in biotechnology (FTE): Technicians and assistants	Fewer than 250 employees	2,423.8
Personnel in R&D in biotechnology (FTE): Technicians and assistants	250 or more employees	1,217.0
Personnel in R&D in biotechnology (FTE): Technicians and assistants	Total	3,640.8
Personnel in R&D in biotechnology (FTE): women	Fewer than 250 employees	3,197.5
Personnel in R&D in biotechnology (FTE): women	250 or more employees	1,501.0
Personnel in R&D in biotechnology (FTE): women	Total	4,698.5
Personnel in R&D in biotechnology (FTE): (women) Researchers	Fewer than 250 employees	1,803.7
Personnel in R&D in biotechnology (FTE): (women) Researchers	250 or more employees	708.8
Personnel in R&D in biotechnology (FTE): (women) Researchers	Total	2,512.5
Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants	Fewer than 250 employees	1,393.8
Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants	250 or more employees	792.2
Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants	Total	2,186.0
Internal expenditure on R&D (thousands of euros)	Fewer than 250 employees	558,184
Internal expenditure on R&D (thousands of euros)	250 or more employees	211,247
Internal expenditure on R&D (thousands of euros)	Total	769,431
1) By nature of the expense: Current expenses	Fewer than 250 employees	518,032
1) By nature of the expense: Current expenses	250 or more employees	201,684
1) By nature of the expense: Current expenses	Total	719,715
1.1) Remuneration to researchers	Fewer than 250 employees	154,555
1.1) Remuneration to researchers	250 or more employees	66,892
1.1) Remuneration to researchers	Total	221,447
1.2) Remuneration to technicians and assistants	Fewer than 250 employees	72,617
1.2) Remuneration to technicians and assistants	250 or more employees	50,192
1.2) Remuneration to technicians and assistants	Total	122,809
1.3) Other current expenses	Fewer than 250 employees	290,860
1.3) Other current expenses	250 or more employees	84,599
1.3) Other current expenses	Total	375,459
2) By nature of the expense: Capital expenses	Fewer than 250 employees	40,152
2) By nature of the expense: Capital expenses	250 or more employees	9,563
2) By nature of the expense: Capital expenses	Total	49,715
2.1) Land and buildings	Fewer than 250 employees	6,661
2.1) Land and buildings	250 or more employees	2,860
2.1) Land and buildings	Total	9,521
2.2) Equipment and instruments	Fewer than 250 employees	24,465
2.2) Equipment and instruments	250 or more employees	6,001
2.2) Equipment and instruments	Total	30,466
2.3) Acquisition of specific R&D software	Fewer than 250 employees	1,157
2.3) Acquisition of specific R&D software	250 or more employees	653
2.3) Acquisition of specific R&D software	Total	1,810
2.4) Otros productos de propiedad intelectual específicos para I+D	Fewer than 250 employees	7,869
2.4) Otros productos de propiedad intelectual específicos para I+D	250 or more employees	49
2.4) Otros productos de propiedad intelectual específicos para I+D	Total	7,919
1.1) By origin of the funds: Own funds	Fewer than 250 employees	385,847
1.1) By origin of the funds: Own funds	250 or more employees	105,066
1.1) By origin of the funds: Own funds	Total	490,913
1.2) By origin of the funds: From companies	Fewer than 250 employees	53,140
1.2) By origin of the funds: From companies	250 or more employees	29,409
1.2) By origin of the funds: From companies	Total	82,548
1.3) By origin of the funds: Public Administration funds	Fewer than 250 employees	64,168
1.3) By origin of the funds: Public Administration funds	250 or more employees	32,641
1.3) By origin of the funds: Public Administration funds	Total	96,809
1.4) By origin of the funds: From Universities	Fewer than 250 employees	197
1.4) By origin of the funds: From Universities	250 or more employees	0
1.4) By origin of the funds: From Universities	Total	197
1.5) By origin of the funds: From non profit private institutions	Fewer than 250 employees	588
1.5) By origin of the funds: From non profit private institutions	250 or more employees	4,177
1.5) By origin of the funds: From non profit private institutions	Total	4,766
1.6) By origin of the funds: Foreign funds	Fewer than 250 employees	54,244
1.6) By origin of the funds: Foreign funds	250 or more employees	39,954
1.6) By origin of the funds: Foreign funds	Total	94,197
Purchase of R&D services in biotechnology (thousands of euros)	Fewer than 250 employees	68,331
Purchase of R&D services in biotechnology (thousands of euros)	250 or more employees	51,951
Purchase of R&D services in biotechnology (thousands of euros)	Total	120,281
Purchase of R&D services in biotechnology (thousands of euros): In Spain	Fewer than 250 employees	22,667
Purchase of R&D services in biotechnology (thousands of euros): In Spain	250 or more employees	46,897
Purchase of R&D services in biotechnology (thousands of euros): In Spain	Total	69,564
Purchase of R&D services in biotechnology (thousands of euros): Abroad	Fewer than 250 employees	45,664
Purchase of R&D services in biotechnology (thousands of euros): Abroad	250 or more employees	5,054
Purchase of R&D services in biotechnology (thousands of euros): Abroad	Total	50,718
%Companies that consider the following obstacles as very important considering biotechnology development: Access to capital	Fewer than 250 employees	47
%Companies that consider the following obstacles as very important considering biotechnology development: Access to capital	250 or more employees	23
%Companies that consider the following obstacles as very important considering biotechnology development: Access to capital	Total	45
%Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information	Fewer than 250 employees	12
%Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information	250 or more employees	13
%Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information	Total	12
%Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources	Fewer than 250 employees	16
%Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources	250 or more employees	15
%Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources	Total	16
%Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain	Fewer than 250 employees	13
%Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain	250 or more employees	15
%Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain	Total	14
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets	Fewer than 250 employees	17
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets	250 or more employees	11
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets	Total	16
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels	Fewer than 250 employees	19
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels	250 or more employees	10
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels	Total	18
%Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception	Fewer than 250 employees	16
%Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception	250 or more employees	13
%Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception	Total	15
%Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements	Fewer than 250 employees	37
%Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements	250 or more employees	29
%Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements	Total	37
%Companies that consider the following obstacles as very important considering biotechnology development: Time / cost	Fewer than 250 employees	53
%Companies that consider the following obstacles as very important considering biotechnology development: Time / cost	250 or more employees	39
%Companies that consider the following obstacles as very important considering biotechnology development: Time / cost	Total	52
%Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting	Fewer than 250 employees	20
%Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting	250 or more employees	14
%Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting	Total	20
% Companies that have requested biotechnology patents in Biotechnology	Fewer than 250 employees	15
% Companies that have requested biotechnology patents in Biotechnology	250 or more employees	17
% Companies that have requested biotechnology patents in Biotechnology	Total	15
Number of patents requested	Fewer than 250 employees	525
Number of patents requested	250 or more employees	156
Number of patents requested	Total	681
% Companies with income of an international origin related to biotechnological activities	Fewer than 250 employees	24.9
% Companies with income of an international origin related to biotechnological activities	250 or more employees	18.4
% Companies with income of an international origin related to biotechnological activities	Total	24.3
% Turnover representing income of an international origin related to biotechnological activities	Fewer than 250 employees	6.00
% Turnover representing income of an international origin related to biotechnological activities	250 or more employees	1.00
% Turnover representing income of an international origin related to biotechnological activities	Total	1.00
% Income of an international origin related to biotechnological activities distributed in: Income received from the EU	Fewer than 250 employees	45.20
% Income of an international origin related to biotechnological activities distributed in: Income received from the EU	250 or more employees	73.10
% Income of an international origin related to biotechnological activities distributed in: Income received from the EU	Total	59.60
% Income of an international origin related to biotechnological activities distributed in: Income received from other countries	Fewer than 250 employees	54.80
% Income of an international origin related to biotechnological activities distributed in: Income received from other countries	250 or more employees	26.90
% Income of an international origin related to biotechnological activities distributed in: Income received from other countries	Total	40.40
% Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services	Fewer than 250 employees	89.00
% Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services	250 or more employees	72.50
% Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services	Total	80.40
% Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain	Fewer than 250 employees	7.50
% Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain	250 or more employees	24.90
% Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain	Total	16.50
% Income of an international origin related with activities according to the classification: Operating source abroad	Fewer than 250 employees	2.20
% Income of an international origin related with activities according to the classification: Operating source abroad	250 or more employees	2.30
% Income of an international origin related with activities according to the classification: Operating source abroad	Total	2.20
% Income of an international origin related with activities according to the classification: Other	Fewer than 250 employees	1.40
% Income of an international origin related with activities according to the classification: Other	250 or more employees	0.40
% Income of an international origin related with activities according to the classification: Other	Total	0.90