Main variables Fields of operation Total Companies that perform R+D in Biotechnology Total 2019 1.399 Companies that perform R+D in Biotechnology Companies 1.198 Companies that perform R+D in Biotechnology P.A. 122 Companies that perform R+D in Biotechnology Higher Education 66 Companies that perform R+D in Biotechnology PNPI 13 %Companies according to biotechnology used: Genetic code Total 2019 40,8 %Companies according to biotechnology used: Genetic code Companies 33,3 %Companies according to biotechnology used: Genetic code P.A. 88,5 %Companies according to biotechnology used: Genetic code Higher Education 87,9 %Companies according to biotechnology used: Genetic code PNPI 38,5 %Companies according to biotechnology used: Functional Companies Total 2019 46,7 %Companies according to biotechnology used: Functional Companies Companies 39,8 %Companies according to biotechnology used: Functional Companies P.A. 88,5 %Companies according to biotechnology used: Functional Companies Higher Education 92,4 %Companies according to biotechnology used: Functional Companies PNPI 53,8 %Companies according to biotechnology used: Cellular and tissue culturing and engineering Total 2019 31,5 %Companies according to biotechnology used: Cellular and tissue culturing and engineering Companies 24,2 %Companies according to biotechnology used: Cellular and tissue culturing and engineering P.A. 73 %Companies according to biotechnology used: Cellular and tissue culturing and engineering Higher Education 83,3 %Companies according to biotechnology used: Cellular and tissue culturing and engineering PNPI 53,8 %Companies according to biotechnology used: Bioprocesses Total 2019 52,4 %Companies according to biotechnology used: Bioprocesses Companies 49,6 %Companies according to biotechnology used: Bioprocesses P.A. 59 %Companies according to biotechnology used: Bioprocesses Higher Education 92,4 %Companies according to biotechnology used: Bioprocesses PNPI 46,2 %Companies according to biotechnology used: Sub-cellular organisms Total 2019 14,4 %Companies according to biotechnology used: Sub-cellular organisms Companies 6,7 %Companies according to biotechnology used: Sub-cellular organisms P.A. 56,6 %Companies according to biotechnology used: Sub-cellular organisms Higher Education 72,7 %Companies according to biotechnology used: Sub-cellular organisms PNPI 38,5 %Companies according to biotechnology used: Bio-computing Total 2019 30,8 %Companies according to biotechnology used: Bio-computing Companies 23,9 %Companies according to biotechnology used: Bio-computing P.A. 71,3 %Companies according to biotechnology used: Bio-computing Higher Education 84,8 %Companies according to biotechnology used: Bio-computing PNPI 15,4 %Companies according to biotechnology used: Nanobiotechnology Total 2019 17,4 %Companies according to biotechnology used: Nanobiotechnology Companies 11,2 %Companies according to biotechnology used: Nanobiotechnology P.A. 50,8 %Companies according to biotechnology used: Nanobiotechnology Higher Education 71,2 %Companies according to biotechnology used: Nanobiotechnology PNPI 7,7 %Companies according to biotechnology used: Other Total 2019 13,9 %Companies according to biotechnology used: Other Companies 14,6 %Companies according to biotechnology used: Other P.A. 7,4 %Companies according to biotechnology used: Other Higher Education 15,2 %Companies according to biotechnology used: Other PNPI 7,7 Companies in which biotechnology activities are: Main and/or exclusive Total 2019 685 Companies in which biotechnology activities are: Main and/or exclusive Companies 644 Companies in which biotechnology activities are: Main and/or exclusive P.A. 33 Companies in which biotechnology activities are: Main and/or exclusive Higher Education 2 Companies in which biotechnology activities are: Main and/or exclusive PNPI 6 Companies in which biotechnology activities are: A secondary line of business Total 2019 253 Companies in which biotechnology activities are: A secondary line of business Companies 171 Companies in which biotechnology activities are: A secondary line of business P.A. 37 Companies in which biotechnology activities are: A secondary line of business Higher Education 43 Companies in which biotechnology activities are: A secondary line of business PNPI 2 Companies in which biotechnology activities are: A tool necessary for production Total 2019 461 Companies in which biotechnology activities are: A tool necessary for production Companies 383 Companies in which biotechnology activities are: A tool necessary for production P.A. 52 Companies in which biotechnology activities are: A tool necessary for production Higher Education 21 Companies in which biotechnology activities are: A tool necessary for production PNPI 5 %Companies by field(s) of ultimate application of biotechnology use: Human health Total 2019 52 %Companies by field(s) of ultimate application of biotechnology use: Human health Companies 47 %Companies by field(s) of ultimate application of biotechnology use: Human health P.A. 77 %Companies by field(s) of ultimate application of biotechnology use: Human health Higher Education 91 %Companies by field(s) of ultimate application of biotechnology use: Human health PNPI 62 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture Total 2019 21 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture Companies 19 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture P.A. 16 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture Higher Education 68 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture PNPI 8 %Companies by field(s) of ultimate application of biotechnology use: Food products Total 2019 33 %Companies by field(s) of ultimate application of biotechnology use: Food products Companies 33 %Companies by field(s) of ultimate application of biotechnology use: Food products P.A. 19 %Companies by field(s) of ultimate application of biotechnology use: Food products Higher Education 80 %Companies by field(s) of ultimate application of biotechnology use: Food products PNPI 8 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production: Total 2019 26 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production: Companies 24 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production: P.A. 20 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production: Higher Education 71 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production: PNPI 23 %Companies by field(s) of ultimate application of biotechnology use: Environment Total 2019 18 %Companies by field(s) of ultimate application of biotechnology use: Environment Companies 15 %Companies by field(s) of ultimate application of biotechnology use: Environment P.A. 21 %Companies by field(s) of ultimate application of biotechnology use: Environment Higher Education 74 %Companies by field(s) of ultimate application of biotechnology use: Environment PNPI 15 %Companies by field(s) of ultimate application of biotechnology use: Industry Total 2019 16 %Companies by field(s) of ultimate application of biotechnology use: Industry Companies 13 %Companies by field(s) of ultimate application of biotechnology use: Industry P.A. 13 %Companies by field(s) of ultimate application of biotechnology use: Industry Higher Education 70 %Companies by field(s) of ultimate application of biotechnology use: Industry PNPI 8 Personnel in R&D in biotechnology (no. of persons) Total 2019 43.523 Personnel in R&D in biotechnology (no. of persons) Companies 13.615 Personnel in R&D in biotechnology (no. of persons) P.A. 14.682 Personnel in R&D in biotechnology (no. of persons) Higher Education 15.063 Personnel in R&D in biotechnology (no. of persons) PNPI 163 Personnel in R&D in biotechnology (no. of persons): Researchers Total 2019 28.702 Personnel in R&D in biotechnology (no. of persons): Researchers Companies 7.436 Personnel in R&D in biotechnology (no. of persons): Researchers P.A. 9.191 Personnel in R&D in biotechnology (no. of persons): Researchers Higher Education 11.968 Personnel in R&D in biotechnology (no. of persons): Researchers PNPI 107 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants Total 2019 14.820 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants Companies 6.178 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants P.A. 5.491 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants Higher Education 3.095 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants PNPI 56 Personnel in R&D in biotechnology (no. of persons): women Total 2019 24.516 Personnel in R&D in biotechnology (no. of persons): women Companies 7.639 Personnel in R&D in biotechnology (no. of persons): women P.A. 9.277 Personnel in R&D in biotechnology (no. of persons): women Higher Education 7.494 Personnel in R&D in biotechnology (no. of persons): women PNPI 106 Personnel in R&D in biotechnology (no. of persons): (women) Researchers Total 2019 15.356 Personnel in R&D in biotechnology (no. of persons): (women) Researchers Companies 4.095 Personnel in R&D in biotechnology (no. of persons): (women) Researchers P.A. 5.444 Personnel in R&D in biotechnology (no. of persons): (women) Researchers Higher Education 5.753 Personnel in R&D in biotechnology (no. of persons): (women) Researchers PNPI 64 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants Total 2019 9.160 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants Companies 3.544 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants P.A. 3.833 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants Higher Education 1.741 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants PNPI 42 Personnel in R&D in biotechnology (FTE) Total 2019 29.655,1 Personnel in R&D in biotechnology (FTE) Companies 9.365,2 Personnel in R&D in biotechnology (FTE) P.A. 11.013,2 Personnel in R&D in biotechnology (FTE) Higher Education 9.177,3 Personnel in R&D in biotechnology (FTE) PNPI 99,4 Personnel in R&D in biotechnology (FTE): Researchers Total 2019 19.150,3 Personnel in R&D in biotechnology (FTE): Researchers Companies 5.410,6 Personnel in R&D in biotechnology (FTE): Researchers P.A. 6.546,6 Personnel in R&D in biotechnology (FTE): Researchers Higher Education 7.128,5 Personnel in R&D in biotechnology (FTE): Researchers PNPI 64,6 Personnel in R&D in biotechnology (FTE): Technicians and assistants Total 2019 10.504,8 Personnel in R&D in biotechnology (FTE): Technicians and assistants Companies 3.954,6 Personnel in R&D in biotechnology (FTE): Technicians and assistants P.A. 4.466,6 Personnel in R&D in biotechnology (FTE): Technicians and assistants Higher Education 2.048,8 Personnel in R&D in biotechnology (FTE): Technicians and assistants PNPI 34,8 Personnel in R&D in biotechnology (FTE): women Total 2019 16.997,1 Personnel in R&D in biotechnology (FTE): women Companies 5.385,8 Personnel in R&D in biotechnology (FTE): women P.A. 6.959,9 Personnel in R&D in biotechnology (FTE): women Higher Education 4.581,4 Personnel in R&D in biotechnology (FTE): women PNPI 70 Personnel in R&D in biotechnology (FTE): (women) Researchers Total 2019 10.349,2 Personnel in R&D in biotechnology (FTE): (women) Researchers Companies 3.032,9 Personnel in R&D in biotechnology (FTE): (women) Researchers P.A. 3.876,1 Personnel in R&D in biotechnology (FTE): (women) Researchers Higher Education 3.397,2 Personnel in R&D in biotechnology (FTE): (women) Researchers PNPI 43 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants Total 2019 6.647,9 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants Companies 2.352,9 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants P.A. 3.083,8 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants Higher Education 1.184,2 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants PNPI 27 Internal expenditure on R&D (thousands of euros) Total 2019 2.040.323 Internal expenditure on R&D (thousands of euros) Companies 940.230 Internal expenditure on R&D (thousands of euros) P.A. 652.393 Internal expenditure on R&D (thousands of euros) Higher Education 442.089 Internal expenditure on R&D (thousands of euros) PNPI 5.611 1) By nature of the expense: Current expenses Total 2019 1.899.869 1) By nature of the expense: Current expenses Companies 871.813 1) By nature of the expense: Current expenses P.A. 608.579 1) By nature of the expense: Current expenses Higher Education 413.960 1) By nature of the expense: Current expenses PNPI 5.517 1.1) Remuneration to researchers Total 2019 776.880 1.1) Remuneration to researchers Companies 284.936 1.1) Remuneration to researchers P.A. 242.168 1.1) Remuneration to researchers Higher Education 247.973 1.1) Remuneration to researchers PNPI 1.802 1.2) Remuneration to technicians and assistants Total 2019 333.017 1.2) Remuneration to technicians and assistants Companies 148.254 1.2) Remuneration to technicians and assistants P.A. 118.062 1.2) Remuneration to technicians and assistants Higher Education 65.769 1.2) Remuneration to technicians and assistants PNPI 931 1.3) Other current expenses Total 2019 789.972 1.3) Other current expenses Companies 438.623 1.3) Other current expenses P.A. 248.348 1.3) Other current expenses Higher Education 100.217 1.3) Other current expenses PNPI 2.784 2) By nature of the expense: Capital expenses Total 2019 140.454 2) By nature of the expense: Capital expenses Companies 68.417 2) By nature of the expense: Capital expenses P.A. 43.814 2) By nature of the expense: Capital expenses Higher Education 28.129 2) By nature of the expense: Capital expenses PNPI 94 2.1) Land and buildings Total 2019 30.677 2.1) Land and buildings Companies 11.763 2.1) Land and buildings P.A. 11.874 2.1) Land and buildings Higher Education 7.040 2.1) Land and buildings PNPI 0 2.2) Equipment and instruments Total 2019 90.306 2.2) Equipment and instruments Companies 39.641 2.2) Equipment and instruments P.A. 31.009 2.2) Equipment and instruments Higher Education 19.567 2.2) Equipment and instruments PNPI 89 2.3) Acquisition of specific R+D software Total 2019 4.900 2.3) Acquisition of specific R+D software Companies 2.831 2.3) Acquisition of specific R+D software P.A. 757 2.3) Acquisition of specific R+D software Higher Education 1.310 2.3) Acquisition of specific R+D software PNPI 3 2.4) Otros productos de propiedad intelectual específicos para I+D Total 2019 14.571 2.4) Otros productos de propiedad intelectual específicos para I+D Companies 14.183 2.4) Otros productos de propiedad intelectual específicos para I+D P.A. 173 2.4) Otros productos de propiedad intelectual específicos para I+D Higher Education 212 2.4) Otros productos de propiedad intelectual específicos para I+D PNPI 2 1.1) By origin of the funds: Own funds Total 2019 742.583 1.1) By origin of the funds: Own funds Companies 577.287 1.1) By origin of the funds: Own funds P.A. 78.505 1.1) By origin of the funds: Own funds Higher Education 86.280 1.1) By origin of the funds: Own funds PNPI 511 1.2) By origin of the funds: From companies Total 2019 268.227 1.2) By origin of the funds: From companies Companies 142.672 1.2) By origin of the funds: From companies P.A. 96.507 1.2) By origin of the funds: From companies Higher Education 28.164 1.2) By origin of the funds: From companies PNPI 884 1.3) By origin of the funds: Public Administration funds Total 2019 783.942 1.3) By origin of the funds: Public Administration funds Companies 102.630 1.3) By origin of the funds: Public Administration funds P.A. 396.610 1.3) By origin of the funds: Public Administration funds Higher Education 282.374 1.3) By origin of the funds: Public Administration funds PNPI 2.327 1.4) By origin of the funds: From Universities Total 2019 2.785 1.4) By origin of the funds: From Universities Companies 457 1.4) By origin of the funds: From Universities P.A. 1.190 1.4) By origin of the funds: From Universities Higher Education 1.138 1.4) By origin of the funds: From Universities PNPI 0 1.5) By origin of the funds: From non profit private institutions Total 2019 30.232 1.5) By origin of the funds: From non profit private institutions Companies 9.631 1.5) By origin of the funds: From non profit private institutions P.A. 13.309 1.5) By origin of the funds: From non profit private institutions Higher Education 5.740 1.5) By origin of the funds: From non profit private institutions PNPI 1.553 1.6) By origin of the funds: Foreign funds Total 2019 212.555 1.6) By origin of the funds: Foreign funds Companies 107.553 1.6) By origin of the funds: Foreign funds P.A. 66.273 1.6) By origin of the funds: Foreign funds Higher Education 38.392 1.6) By origin of the funds: Foreign funds PNPI 336 Purchase of services R & D in Biotechnology to (thousands of euros) Total 2019 133.151 Purchase of services R & D in Biotechnology to (thousands of euros) Companies 114.839 Purchase of services R & D in Biotechnology to (thousands of euros) P.A. 12.728 Purchase of services R & D in Biotechnology to (thousands of euros) Higher Education 5.216 Purchase of services R & D in Biotechnology to (thousands of euros) PNPI 368 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain Total 2019 85.933 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain Companies 69.258 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain P.A. 11.630 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain Higher Education 4.727 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain PNPI 318 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad Total 2019 47.219 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad Companies 45.581 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad P.A. 1.098 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad Higher Education 489 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad PNPI 51 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital Total 2019 44,2 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital Companies 41,8 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital P.A. 57,4 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital Higher Education 56,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital PNPI 76,9 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information Total 2019 11,3 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information Companies 12 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information P.A. 2,5 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information Higher Education 12,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information PNPI 23,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources Total 2019 16,8 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources Companies 13,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources P.A. 39,3 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources Higher Education 40,9 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources PNPI 30,8 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain Total 2019 13,4 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain Companies 10,7 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain P.A. 28,7 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain Higher Education 33,3 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain PNPI 23,1 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets Total 2019 18,1 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets Companies 15,1 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets P.A. 32,8 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets Higher Education 42,4 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets PNPI 30,8 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels Total 2019 18 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels Companies 16 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels P.A. 30 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels Higher Education 41 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels PNPI 23 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception Total 2019 15,2 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception Companies 15,9 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception P.A. 9 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception Higher Education 10,6 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception PNPI 38,5 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements Total 2019 37 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements Companies 37 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements P.A. 41 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements Higher Education 36 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements PNPI 39 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost Total 2019 51,9 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost Companies 50,7 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost P.A. 57,4 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost Higher Education 63,6 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost PNPI 53,8 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting Total 2019 19,1 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting Companies 19 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting P.A. 20,5 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting Higher Education 16,7 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting PNPI 30,8 %Companies that have requested biotechnology patents in Biotechnology Total 2019 23,7 %Companies that have requested biotechnology patents in Biotechnology Companies 18,3 %Companies that have requested biotechnology patents in Biotechnology P.A. 53,3 %Companies that have requested biotechnology patents in Biotechnology Higher Education 69,7 %Companies that have requested biotechnology patents in Biotechnology PNPI 7,7 Number of patents requested Total 2019 1.846 Number of patents requested Companies 643 Number of patents requested P.A. 667 Number of patents requested Higher Education 535 Number of patents requested PNPI 1