Main variables;No. of employees;Total No. of companies carrying out R&D in Biotechnology;Fewer than 250 employees;1.126 No. of companies carrying out R&D in Biotechnology;250 or more employees;108 No. of companies carrying out R&D in Biotechnology;Total 2020;1.233 %Companies according to biotechnology used: Genetic code;Fewer than 250 employees;30,9 %Companies according to biotechnology used: Genetic code;250 or more employees;40,2 %Companies according to biotechnology used: Genetic code;Total 2020;31,7 %Companies according to biotechnology used: Functional units;Fewer than 250 employees;37,4 %Companies according to biotechnology used: Functional units;250 or more employees;50,4 %Companies according to biotechnology used: Functional units;Total 2020;38,5 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;Fewer than 250 employees;21,6 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;250 or more employees;34,5 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;Total 2020;22,8 %Companies according to biotechnology used: Bioprocesses;Fewer than 250 employees;51,7 %Companies according to biotechnology used: Bioprocesses;250 or more employees;71 %Companies according to biotechnology used: Bioprocesses;Total 2020;53,4 %Companies according to biotechnology used: Sub-cellular organisms;Fewer than 250 employees;7,8 %Companies according to biotechnology used: Sub-cellular organisms;250 or more employees;16,8 %Companies according to biotechnology used: Sub-cellular organisms;Total 2020;8,6 %Companies according to biotechnology used: Bio-computing;Fewer than 250 employees;22,2 %Companies according to biotechnology used: Bio-computing;250 or more employees;22,3 %Companies according to biotechnology used: Bio-computing;Total 2020;22,3 %Companies according to biotechnology used: Nanobiotechnology;Fewer than 250 employees;10,5 %Companies according to biotechnology used: Nanobiotechnology;250 or more employees;12,1 %Companies according to biotechnology used: Nanobiotechnology;Total 2020;10,6 %Companies according to biotechnology used: Other;Fewer than 250 employees;14,7 %Companies according to biotechnology used: Other;250 or more employees;9,3 %Companies according to biotechnology used: Other;Total 2020;14,2 Companies in which biotechnology activities are: Main and/or exclusive;Fewer than 250 employees;590 Companies in which biotechnology activities are: Main and/or exclusive;250 or more employees;25 Companies in which biotechnology activities are: Main and/or exclusive;Total 2020;615 Companies in which biotechnology activities are: A secondary line of business;Fewer than 250 employees;156 Companies in which biotechnology activities are: A secondary line of business;250 or more employees;22 Companies in which biotechnology activities are: A secondary line of business;Total 2020;178 Companies in which biotechnology activities are: A tool necessary for production;Fewer than 250 employees;379 Companies in which biotechnology activities are: A tool necessary for production;250 or more employees;61 Companies in which biotechnology activities are: A tool necessary for production;Total 2020;440 %Company by field(s) of ultimate application of biotechnology use: Human Health;Fewer than 250 employees;46,2 %Company by field(s) of ultimate application of biotechnology use: Human Health;250 or more employees;46,5 %Company by field(s) of ultimate application of biotechnology use: Human Health;Total 2020;46,3 %Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;Fewer than 250 employees;16,9 %Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;250 or more employees;9,3 %Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;Total 2020;16,2 %Company by field(s) of ultimate application of biotechnology use: Food products;Fewer than 250 employees;31,7 %Company by field(s) of ultimate application of biotechnology use: Food products;250 or more employees;35,6 %Company by field(s) of ultimate application of biotechnology use: Food products;Total 2020;32 %Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production;Fewer than 250 employees;25,6 %Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production;250 or more employees;14,1 %Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production;Total 2020;24,6 %Company by field(s) of ultimate application of biotechnology use: Environment;Fewer than 250 employees;15,3 %Company by field(s) of ultimate application of biotechnology use: Environment;250 or more employees;17,7 %Company by field(s) of ultimate application of biotechnology use: Environment;Total 2020;15,5 %Company by field(s) of ultimate application of biotechnology use: Industry;Fewer than 250 employees;13,1 %Company by field(s) of ultimate application of biotechnology use: Industry;250 or more employees;11,1 %Company by field(s) of ultimate application of biotechnology use: Industry;Total 2020;12,9 Personnel in R&D in biotechnology (no. of persons);Fewer than 250 employees;9.325 Personnel in R&D in biotechnology (no. of persons);250 or more employees;4.119 Personnel in R&D in biotechnology (no. of persons);Total 2020;13.444 Personnel in R&D in biotechnology (no. of persons): Researchers;Fewer than 250 employees;5.272 Personnel in R&D in biotechnology (no. of persons): Researchers;250 or more employees;2.106 Personnel in R&D in biotechnology (no. of persons): Researchers;Total 2020;7.378 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants;Fewer than 250 employees;4.053 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants;250 or more employees;2.013 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants;Total 2020;6.066 Personnel in R&D in biotechnology (no. of persons): women;Fewer than 250 employees;4.869 Personnel in R&D in biotechnology (no. of persons): women;250 or more employees;2.632 Personnel in R&D in biotechnology (no. of persons): women;Total 2020;7.501 Personnel in R&D in biotechnology (no. of persons): (women) Researchers;Fewer than 250 employees;2.752 Personnel in R&D in biotechnology (no. of persons): (women) Researchers;250 or more employees;1.299 Personnel in R&D in biotechnology (no. of persons): (women) Researchers;Total 2020;4.052 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants;Fewer than 250 employees;2.117 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants;250 or more employees;1.333 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants;Total 2020;3.450 Personnel in R&D in biotechnology (FTE);Fewer than 250 employees;6.291,5 Personnel in R&D in biotechnology (FTE);250 or more employees;3.110,4 Personnel in R&D in biotechnology (FTE);Total 2020;9.401,9 Personnel in R&D in biotechnology (FTE): Researchers;Fewer than 250 employees;3.811,8 Personnel in R&D in biotechnology (FTE): Researchers;250 or more employees;1.586,5 Personnel in R&D in biotechnology (FTE): Researchers;Total 2020;5.398,3 Personnel in R&D in biotechnology (FTE): Technicians and assistants;Fewer than 250 employees;2.479,7 Personnel in R&D in biotechnology (FTE): Technicians and assistants;250 or more employees;1.523,9 Personnel in R&D in biotechnology (FTE): Technicians and assistants;Total 2020;4.003,6 Personnel in R&D in biotechnology (FTE): women;Fewer than 250 employees;3.385,8 Personnel in R&D in biotechnology (FTE): women;250 or more employees;2.040,5 Personnel in R&D in biotechnology (FTE): women;Total 2020;5.426,2 Personnel in R&D in biotechnology (FTE): (women) Researchers;Fewer than 250 employees;2.020,5 Personnel in R&D in biotechnology (FTE): (women) Researchers;250 or more employees;996 Personnel in R&D in biotechnology (FTE): (women) Researchers;Total 2020;3.016,4 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants;Fewer than 250 employees;1.365,3 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants;250 or more employees;1.044,5 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants;Total 2020;2.409,8 Internal expenditure on R&D (thousands of euros);Fewer than 250 employees;586.635 Internal expenditure on R&D (thousands of euros);250 or more employees;310.698 Internal expenditure on R&D (thousands of euros);Total 2020;897.333 1) By nature of the expense: Current expenses;Fewer than 250 employees;520.977 1) By nature of the expense: Current expenses;250 or more employees;296.432 1) By nature of the expense: Current expenses;Total 2020;817.409 1.1) Remuneration to researchers;Fewer than 250 employees;182.849 1.1) Remuneration to researchers;250 or more employees;112.856 1.1) Remuneration to researchers;Total 2020;295.705 1.2) Remuneration to technicians and assistants;Fewer than 250 employees;90.123 1.2) Remuneration to technicians and assistants;250 or more employees;66.730 1.2) Remuneration to technicians and assistants;Total 2020;156.853 1.3) Other current expenses;Fewer than 250 employees;248.005 1.3) Other current expenses;250 or more employees;116.847 1.3) Other current expenses;Total 2020;364.852 2) By nature of the expense: Capital expenses;Fewer than 250 employees;65.658 2) By nature of the expense: Capital expenses;250 or more employees;14.266 2) By nature of the expense: Capital expenses;Total 2020;79.924 2.1) Land and buildings;Fewer than 250 employees;6.331 2.1) Land and buildings;250 or more employees;3.941 2.1) Land and buildings;Total 2020;10.272 2.2) Equipment and instruments;Fewer than 250 employees;46.970 2.2) Equipment and instruments;250 or more employees;9.640 2.2) Equipment and instruments;Total 2020;56.609 2.3) Acquisition of specific R&D software;Fewer than 250 employees;4.475 2.3) Acquisition of specific R&D software;250 or more employees;364 2.3) Acquisition of specific R&D software;Total 2020;4.839 2.4) Otros productos de propiedad intelectual específicos para I+D;Fewer than 250 employees;7.882 2.4) Otros productos de propiedad intelectual específicos para I+D;250 or more employees;321 2.4) Otros productos de propiedad intelectual específicos para I+D;Total 2020;8.203 1.1) By origin of the funds: Own funds;Fewer than 250 employees;406.605 1.1) By origin of the funds: Own funds;250 or more employees;206.492 1.1) By origin of the funds: Own funds;Total 2020;613.097 1.2) By origin of the funds: From companies;Fewer than 250 employees;62.831 1.2) By origin of the funds: From companies;250 or more employees;23.253 1.2) By origin of the funds: From companies;Total 2020;86.085 1.3) By origin of the funds: Public Administration funds;Fewer than 250 employees;71.590 1.3) By origin of the funds: Public Administration funds;250 or more employees;20.550 1.3) By origin of the funds: Public Administration funds;Total 2020;92.140 1.4) By origin of the funds: From Universities;Fewer than 250 employees;548 1.4) By origin of the funds: From Universities;250 or more employees;306 1.4) By origin of the funds: From Universities;Total 2020;853 1.5) By origin of the funds: From non profit private institutions;Fewer than 250 employees;2.496 1.5) By origin of the funds: From non profit private institutions;250 or more employees;2.185 1.5) By origin of the funds: From non profit private institutions;Total 2020;4.682 1.6) By origin of the funds: Foreign funds;Fewer than 250 employees;42.564 1.6) By origin of the funds: Foreign funds;250 or more employees;57.912 1.6) By origin of the funds: Foreign funds;Total 2020;100.476 Purchase of R&D services in biotechnology (thousands of euros);Fewer than 250 employees;48.478 Purchase of R&D services in biotechnology (thousands of euros);250 or more employees;36.533 Purchase of R&D services in biotechnology (thousands of euros);Total 2020;85.011 Purchase of R&D services in biotechnology (thousands of euros): In Spain;Fewer than 250 employees;23.128 Purchase of R&D services in biotechnology (thousands of euros): In Spain;250 or more employees;31.114 Purchase of R&D services in biotechnology (thousands of euros): In Spain;Total 2020;54.243 Purchase of R&D services in biotechnology (thousands of euros): Abroad;Fewer than 250 employees;25.350 Purchase of R&D services in biotechnology (thousands of euros): Abroad;250 or more employees;5.419 Purchase of R&D services in biotechnology (thousands of euros): Abroad;Total 2020;30.768 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;Fewer than 250 employees;40,9 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;250 or more employees;22,4 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;Total 2020;39,2 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;Fewer than 250 employees;11,5 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;250 or more employees;14 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;Total 2020;11,7 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;Fewer than 250 employees;12,9 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;250 or more employees;8,4 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;Total 2020;12,5 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;Fewer than 250 employees;10,8 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;250 or more employees;11,2 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;Total 2020;10,9 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;Fewer than 250 employees;14,7 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;250 or more employees;10,3 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;Total 2020;14,3 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels;Fewer than 250 employees;17,4 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels;250 or more employees;7,5 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels;Total 2020;16,5 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;Fewer than 250 employees;15,2 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;250 or more employees;13,1 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;Total 2020;15 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;Fewer than 250 employees;36 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;250 or more employees;31 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;Total 2020;36 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;Fewer than 250 employees;47,2 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;250 or more employees;41 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;Total 2020;46,7 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;Fewer than 250 employees;19,3 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;250 or more employees;15,9 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;Total 2020;19 % Companies that have requested biotechnology patents in Biotechnology;Fewer than 250 employees;17,3 % Companies that have requested biotechnology patents in Biotechnology;250 or more employees;17,7 % Companies that have requested biotechnology patents in Biotechnology;Total 2020;17,3 Number of patents requested;Fewer than 250 employees;600 Number of patents requested;250 or more employees;81 Number of patents requested;Total 2020;681 % Companies with income of an international origin related to biotechnological activities;Fewer than 250 employees;23,6 % Companies with income of an international origin related to biotechnological activities;250 or more employees;16,8 % Companies with income of an international origin related to biotechnological activities;Total 2020;23 % Turnover representing income of an international origin related to biotechnological activities;Fewer than 250 employees;5,6 % Turnover representing income of an international origin related to biotechnological activities;250 or more employees;0,9 % Turnover representing income of an international origin related to biotechnological activities;Total 2020;1,6 % Income of an international origin related to biotechnological activities distributed in: Income received from the EU;Fewer than 250 employees;44,7 % Income of an international origin related to biotechnological activities distributed in: Income received from the EU;250 or more employees;69,7 % Income of an international origin related to biotechnological activities distributed in: Income received from the EU;Total 2020;55,9 % Income of an international origin related to biotechnological activities distributed in: Income received from other countries;Fewer than 250 employees;55,3 % Income of an international origin related to biotechnological activities distributed in: Income received from other countries;250 or more employees;30,3 % Income of an international origin related to biotechnological activities distributed in: Income received from other countries;Total 2020;44,1 % Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services;Fewer than 250 employees;97,2 % Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services;250 or more employees;67,6 % Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services;Total 2020;83,9 % Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Fewer than 250 employees;1,1 % Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;250 or more employees;31,5 % Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Total 2020;14,7 % Income of an international origin related with activities according to the classification: Operating source abroad;Fewer than 250 employees;0,7 % Income of an international origin related with activities according to the classification: Operating source abroad;250 or more employees;0,9 % Income of an international origin related with activities according to the classification: Operating source abroad;Total 2020;0,8 % Income of an international origin related with activities according to the classification: Other;Fewer than 250 employees;1,1 % Income of an international origin related with activities according to the classification: Other;250 or more employees;0 % Income of an international origin related with activities according to the classification: Other;Total 2020;0,6