Main variables;Fields of operation;Total Companies that perform R+D in Biotechnology;Total 2021;1.498 Companies that perform R+D in Biotechnology;Companies;1.299 Companies that perform R+D in Biotechnology;P.A.;120 Companies that perform R+D in Biotechnology;Higher Education;66 Companies that perform R+D in Biotechnology;PNPI;13 %Companies according to biotechnology used: Genetic code;Total 2021;38 %Companies according to biotechnology used: Genetic code;Companies;30,8 %Companies according to biotechnology used: Genetic code;P.A.;87,5 %Companies according to biotechnology used: Genetic code;Higher Education;89,4 %Companies according to biotechnology used: Genetic code;PNPI;46,2 %Companies according to biotechnology used: Functional Companies;Total 2021;45 %Companies according to biotechnology used: Functional Companies;Companies;38,4 %Companies according to biotechnology used: Functional Companies;P.A.;88,3 %Companies according to biotechnology used: Functional Companies;Higher Education;93,9 %Companies according to biotechnology used: Functional Companies;PNPI;53,8 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;Total 2021;28,9 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;Companies;21,5 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;P.A.;73,3 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;Higher Education;86,4 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;PNPI;61,5 %Companies according to biotechnology used: Bioprocesses;Total 2021;53,4 %Companies according to biotechnology used: Bioprocesses;Companies;50,8 %Companies according to biotechnology used: Bioprocesses;P.A.;58,3 %Companies according to biotechnology used: Bioprocesses;Higher Education;93,9 %Companies according to biotechnology used: Bioprocesses;PNPI;69,2 %Companies according to biotechnology used: Sub-cellular organisms;Total 2021;15,2 %Companies according to biotechnology used: Sub-cellular organisms;Companies;8,5 %Companies according to biotechnology used: Sub-cellular organisms;P.A.;53,3 %Companies according to biotechnology used: Sub-cellular organisms;Higher Education;74,2 %Companies according to biotechnology used: Sub-cellular organisms;PNPI;38,5 %Companies according to biotechnology used: Bio-computing;Total 2021;30,8 %Companies according to biotechnology used: Bio-computing;Companies;24 %Companies according to biotechnology used: Bio-computing;P.A.;73,3 %Companies according to biotechnology used: Bio-computing;Higher Education;87,9 %Companies according to biotechnology used: Bio-computing;PNPI;30,8 %Companies according to biotechnology used: Nanobiotechnology;Total 2021;18,2 %Companies according to biotechnology used: Nanobiotechnology;Companies;12,1 %Companies according to biotechnology used: Nanobiotechnology;P.A.;54,2 %Companies according to biotechnology used: Nanobiotechnology;Higher Education;72,7 %Companies according to biotechnology used: Nanobiotechnology;PNPI;15,4 %Companies according to biotechnology used: Other;Total 2021;15,3 %Companies according to biotechnology used: Other;Companies;16,9 %Companies according to biotechnology used: Other;P.A.;3,3 %Companies according to biotechnology used: Other;Higher Education;7,6 %Companies according to biotechnology used: Other;PNPI;0 Companies in which biotechnology activities are: Main and/or exclusive;Total 2021;603 Companies in which biotechnology activities are: Main and/or exclusive;Companies;559 Companies in which biotechnology activities are: Main and/or exclusive;P.A.;31 Companies in which biotechnology activities are: Main and/or exclusive;Higher Education;3 Companies in which biotechnology activities are: Main and/or exclusive;PNPI;10 Companies in which biotechnology activities are: A secondary line of business;Total 2021;318 Companies in which biotechnology activities are: A secondary line of business;Companies;230 Companies in which biotechnology activities are: A secondary line of business;P.A.;41 Companies in which biotechnology activities are: A secondary line of business;Higher Education;46 Companies in which biotechnology activities are: A secondary line of business;PNPI;1 Companies in which biotechnology activities are: A tool necessary for production;Total 2021;577 Companies in which biotechnology activities are: A tool necessary for production;Companies;510 Companies in which biotechnology activities are: A tool necessary for production;P.A.;48 Companies in which biotechnology activities are: A tool necessary for production;Higher Education;17 Companies in which biotechnology activities are: A tool necessary for production;PNPI;2 %Companies by field(s) of ultimate application of biotechnology use: Human health;Total 2021;50,4 %Companies by field(s) of ultimate application of biotechnology use: Human health;Companies;45,5 %Companies by field(s) of ultimate application of biotechnology use: Human health;P.A.;76,7 %Companies by field(s) of ultimate application of biotechnology use: Human health;Higher Education;95,5 %Companies by field(s) of ultimate application of biotechnology use: Human health;PNPI;69,2 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;Total 2021;18,1 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;Companies;15,5 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;P.A.;17,5 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;Higher Education;69,7 %Companies by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;PNPI;23,1 %Companies by field(s) of ultimate application of biotechnology use: Food products;Total 2021;33,6 %Companies by field(s) of ultimate application of biotechnology use: Food products;Companies;32,3 %Companies by field(s) of ultimate application of biotechnology use: Food products;P.A.;24,2 %Companies by field(s) of ultimate application of biotechnology use: Food products;Higher Education;81,8 %Companies by field(s) of ultimate application of biotechnology use: Food products;PNPI;7,7 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production;Total 2021;25,8 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production;Companies;23,8 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production;P.A.;22,5 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production;Higher Education;72,7 %Companies by field(s) of ultimate application of biotechnology use: Agriculture and forest production;PNPI;23,1 %Companies by field(s) of ultimate application of biotechnology use: Environment;Total 2021;19,1 %Companies by field(s) of ultimate application of biotechnology use: Environment;Companies;15,6 %Companies by field(s) of ultimate application of biotechnology use: Environment;P.A.;25,8 %Companies by field(s) of ultimate application of biotechnology use: Environment;Higher Education;78,8 %Companies by field(s) of ultimate application of biotechnology use: Environment;PNPI;7,7 %Companies by field(s) of ultimate application of biotechnology use: Industry;Total 2021;16,1 %Companies by field(s) of ultimate application of biotechnology use: Industry;Companies;13,7 %Companies by field(s) of ultimate application of biotechnology use: Industry;P.A.;14,2 %Companies by field(s) of ultimate application of biotechnology use: Industry;Higher Education;68,2 %Companies by field(s) of ultimate application of biotechnology use: Industry;PNPI;7,7 Personnel in R&D in biotechnology (no. of persons);Total 2021;47.150 Personnel in R&D in biotechnology (no. of persons);Companies;15.750 Personnel in R&D in biotechnology (no. of persons);P.A.;15.418 Personnel in R&D in biotechnology (no. of persons);Higher Education;15.757 Personnel in R&D in biotechnology (no. of persons);PNPI;225 Personnel in R&D in biotechnology (no. of persons): Research personnel;Total 2021;30.817 Personnel in R&D in biotechnology (no. of persons): Research personnel;Companies;8.379 Personnel in R&D in biotechnology (no. of persons): Research personnel;P.A.;9.510 Personnel in R&D in biotechnology (no. of persons): Research personnel;Higher Education;12.778 Personnel in R&D in biotechnology (no. of persons): Research personnel;PNPI;150 Personnel in R&D in biotechnology (no. of persons): Technical and auxiliary personnel;Total 2021;16.333 Personnel in R&D in biotechnology (no. of persons): Technical and auxiliary personnel;Companies;7.371 Personnel in R&D in biotechnology (no. of persons): Technical and auxiliary personnel;P.A.;5.908 Personnel in R&D in biotechnology (no. of persons): Technical and auxiliary personnel;Higher Education;2.979 Personnel in R&D in biotechnology (no. of persons): Technical and auxiliary personnel;PNPI;75 Personnel in R&D in biotechnology (no. of persons). Women;Total 2021;26.632 Personnel in R&D in biotechnology (no. of persons). Women;Companies;8.711 Personnel in R&D in biotechnology (no. of persons). Women;P.A.;9.684 Personnel in R&D in biotechnology (no. of persons). Women;Higher Education;8.101 Personnel in R&D in biotechnology (no. of persons). Women;PNPI;136 Personnel in R&D in biotechnology (no. of persons). Women. Research personnel;Total 2021;16.540 Personnel in R&D in biotechnology (no. of persons). Women. Research personnel;Companies;4.510 Personnel in R&D in biotechnology (no. of persons). Women. Research personnel;P.A.;5.637 Personnel in R&D in biotechnology (no. of persons). Women. Research personnel;Higher Education;6.314 Personnel in R&D in biotechnology (no. of persons). Women. Research personnel;PNPI;79 Personnel in R&D in biotechnology (no. of persons). Women. Technical and auxiliary personnel;Total 2021;10.091 Personnel in R&D in biotechnology (no. of persons). Women. Technical and auxiliary personnel;Companies;4.200 Personnel in R&D in biotechnology (no. of persons). Women. Technical and auxiliary personnel;P.A.;4.047 Personnel in R&D in biotechnology (no. of persons). Women. Technical and auxiliary personnel;Higher Education;1.787 Personnel in R&D in biotechnology (no. of persons). Women. Technical and auxiliary personnel;PNPI;57 Personnel in R&D in biotechnology (FTE);Total 2021;32.901,7 Personnel in R&D in biotechnology (FTE);Companies;11.528,6 Personnel in R&D in biotechnology (FTE);P.A.;11.271,7 Personnel in R&D in biotechnology (FTE);Higher Education;9.934,5 Personnel in R&D in biotechnology (FTE);PNPI;166,9 Personnel in R&D in biotechnology (FTE): Research personnel;Total 2021;20.945,8 Personnel in R&D in biotechnology (FTE): Research personnel;Companies;6.342,7 Personnel in R&D in biotechnology (FTE): Research personnel;P.A.;6.454,3 Personnel in R&D in biotechnology (FTE): Research personnel;Higher Education;8.036 Personnel in R&D in biotechnology (FTE): Research personnel;PNPI;112,8 Personnel in R&D in biotechnology (FTE): Technical and auxiliary personnel;Total 2021;11.955,9 Personnel in R&D in biotechnology (FTE): Technical and auxiliary personnel;Companies;5.185,9 Personnel in R&D in biotechnology (FTE): Technical and auxiliary personnel;P.A.;4.817,4 Personnel in R&D in biotechnology (FTE): Technical and auxiliary personnel;Higher Education;1.898,5 Personnel in R&D in biotechnology (FTE): Technical and auxiliary personnel;PNPI;54,1 Personnel in R&D in biotechnology (FTE). Women;Total 2021;18.952,5 Personnel in R&D in biotechnology (FTE). Women;Companies;6.539,7 Personnel in R&D in biotechnology (FTE). Women;P.A.;7.077,3 Personnel in R&D in biotechnology (FTE). Women;Higher Education;5.228 Personnel in R&D in biotechnology (FTE). Women;PNPI;107,5 Personnel in R&D in biotechnology (FTE). Women: Research personnel;Total 2021;11.337,3 Personnel in R&D in biotechnology (FTE). Women: Research personnel;Companies;3.455,7 Personnel in R&D in biotechnology (FTE). Women: Research personnel;P.A.;3.786,8 Personnel in R&D in biotechnology (FTE). Women: Research personnel;Higher Education;4.032,9 Personnel in R&D in biotechnology (FTE). Women: Research personnel;PNPI;61,9 Personnel in R&D in biotechnology (FTE). Women: Technical and auxiliary personnel;Total 2021;7.615,2 Personnel in R&D in biotechnology (FTE). Women: Technical and auxiliary personnel;Companies;3.084 Personnel in R&D in biotechnology (FTE). Women: Technical and auxiliary personnel;P.A.;3.290,5 Personnel in R&D in biotechnology (FTE). Women: Technical and auxiliary personnel;Higher Education;1.195,1 Personnel in R&D in biotechnology (FTE). Women: Technical and auxiliary personnel;PNPI;45,6 Internal expenditure on R&D (thousands of euros);Total 2021;2.269.946 Internal expenditure on R&D (thousands of euros);Companies;1.038.582 Internal expenditure on R&D (thousands of euros);P.A.;716.877 Internal expenditure on R&D (thousands of euros);Higher Education;500.703 Internal expenditure on R&D (thousands of euros);PNPI;13.783 1) By nature of the expense: Current expenses;Total 2021;2.087.088 1) By nature of the expense: Current expenses;Companies;940.091 1) By nature of the expense: Current expenses;P.A.;672.607 1) By nature of the expense: Current expenses;Higher Education;461.216 1) By nature of the expense: Current expenses;PNPI;13.174 1.1) Remuneration to research personnel;Total 2021;872.195 1.1) Remuneration to research personnel;Companies;321.570 1.1) Remuneration to research personnel;P.A.;252.863 1.1) Remuneration to research personnel;Higher Education;293.131 1.1) Remuneration to research personnel;PNPI;4.630 1.2) Remuneration to technicians and auxiliary personnel;Total 2021;384.422 1.2) Remuneration to technicians and auxiliary personnel;Companies;194.836 1.2) Remuneration to technicians and auxiliary personnel;P.A.;128.640 1.2) Remuneration to technicians and auxiliary personnel;Higher Education;59.408 1.2) Remuneration to technicians and auxiliary personnel;PNPI;1.538 1.3) Other current expenses;Total 2021;830.471 1.3) Other current expenses;Companies;423.685 1.3) Other current expenses;P.A.;291.103 1.3) Other current expenses;Higher Education;108.677 1.3) Other current expenses;PNPI;7.006 2) By nature of the expense: Capital expenses;Total 2021;182.858 2) By nature of the expense: Capital expenses;Companies;98.492 2) By nature of the expense: Capital expenses;P.A.;44.270 2) By nature of the expense: Capital expenses;Higher Education;39.487 2) By nature of the expense: Capital expenses;PNPI;610 2.1) Land and buildings;Total 2021;20.307 2.1) Land and buildings;Companies;10.199 2.1) Land and buildings;P.A.;2.712 2.1) Land and buildings;Higher Education;7.373 2.1) Land and buildings;PNPI;23 2.2) Equipment and instruments;Total 2021;144.143 2.2) Equipment and instruments;Companies;72.584 2.2) Equipment and instruments;P.A.;40.235 2.2) Equipment and instruments;Higher Education;30.775 2.2) Equipment and instruments;PNPI;549 2.3) Acquisition of specific R+D software;Total 2021;8.159 2.3) Acquisition of specific R+D software;Companies;5.721 2.3) Acquisition of specific R+D software;P.A.;1.102 2.3) Acquisition of specific R+D software;Higher Education;1.303 2.3) Acquisition of specific R+D software;PNPI;33 2.4) Otros productos de propiedad intelectual específicos para I+D;Total 2021;10.250 2.4) Otros productos de propiedad intelectual específicos para I+D;Companies;9.987 2.4) Otros productos de propiedad intelectual específicos para I+D;P.A.;222 2.4) Otros productos de propiedad intelectual específicos para I+D;Higher Education;36 2.4) Otros productos de propiedad intelectual específicos para I+D;PNPI;5 1.1) By origin of the funds: Own funds;Total 2021;891.566 1.1) By origin of the funds: Own funds;Companies;711.488 1.1) By origin of the funds: Own funds;P.A.;88.338 1.1) By origin of the funds: Own funds;Higher Education;88.167 1.1) By origin of the funds: Own funds;PNPI;3.574 1.2) By origin of the funds: From companies;Total 2021;248.128 1.2) By origin of the funds: From companies;Companies;121.738 1.2) By origin of the funds: From companies;P.A.;97.993 1.2) By origin of the funds: From companies;Higher Education;25.096 1.2) By origin of the funds: From companies;PNPI;3.301 1.3) By origin of the funds: Public Administration funds;Total 2021;882.585 1.3) By origin of the funds: Public Administration funds;Companies;107.477 1.3) By origin of the funds: Public Administration funds;P.A.;430.689 1.3) By origin of the funds: Public Administration funds;Higher Education;342.018 1.3) By origin of the funds: Public Administration funds;PNPI;2.402 1.4) By origin of the funds: From Universities;Total 2021;3.851 1.4) By origin of the funds: From Universities;Companies;192 1.4) By origin of the funds: From Universities;P.A.;1.388 1.4) By origin of the funds: From Universities;Higher Education;2.220 1.4) By origin of the funds: From Universities;PNPI;50 1.5) By origin of the funds: From non profit private institutions;Total 2021;47.810 1.5) By origin of the funds: From non profit private institutions;Companies;10.756 1.5) By origin of the funds: From non profit private institutions;P.A.;26.599 1.5) By origin of the funds: From non profit private institutions;Higher Education;7.719 1.5) By origin of the funds: From non profit private institutions;PNPI;2.737 1.6) By origin of the funds: Foreign funds;Total 2021;196.006 1.6) By origin of the funds: Foreign funds;Companies;86.931 1.6) By origin of the funds: Foreign funds;P.A.;71.871 1.6) By origin of the funds: Foreign funds;Higher Education;35.483 1.6) By origin of the funds: Foreign funds;PNPI;1.720 Purchase of services R & D in Biotechnology to (thousands of euros);Total 2021;174.934 Purchase of services R & D in Biotechnology to (thousands of euros);Companies;145.557 Purchase of services R & D in Biotechnology to (thousands of euros);P.A.;23.461 Purchase of services R & D in Biotechnology to (thousands of euros);Higher Education;3.058 Purchase of services R & D in Biotechnology to (thousands of euros);PNPI;2.858 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain;Total 2021;123.461 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain;Companies;95.915 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain;P.A.;21.807 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain;Higher Education;3.035 Purchase of services R & D in Biotechnology to (thousands of euros): in Spain;PNPI;2.704 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad;Total 2021;51.472 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad;Companies;49.642 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad;P.A.;1.654 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad;Higher Education;23 Purchase of services R & D in Biotechnology to (thousands of euros): Abroad;PNPI;154 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;Total 2021;43 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;Companies;40,2 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;P.A.;63,3 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;Higher Education;57,6 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;PNPI;61,5 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;Total 2021;12,5 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;Companies;13,2 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;P.A.;6,7 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;Higher Education;9,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;PNPI;15,4 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;Total 2021;22,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;Companies;19 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;P.A.;45 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;Higher Education;40,9 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;PNPI;23,1 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;Total 2021;13,6 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;Companies;11,5 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;P.A.;26,7 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;Higher Education;33,3 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;PNPI;7,7 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;Total 2021;18,2 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;Companies;15,9 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;P.A.;30 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;Higher Education;42,4 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;PNPI;15,4 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels;Total 2021;18,9 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels;Companies;17 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels;P.A.;27,5 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels;Higher Education;39,4 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and marketing channels;PNPI;30,8 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;Total 2021;15,9 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;Companies;16,4 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;P.A.;10 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;Higher Education;12,1 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;PNPI;30,8 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;Total 2021;40,5 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;Companies;40,5 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;P.A.;40 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;Higher Education;37,9 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;PNPI;61,5 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;Total 2021;55,4 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;Companies;55 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;P.A.;58,3 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;Higher Education;57,6 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;PNPI;61,5 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;Total 2021;21,9 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;Companies;21,9 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;P.A.;24,2 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;Higher Education;18,2 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;PNPI;23,1