Indicator type;Size of the company;Total Number of companies carrying out R&D in Biotechnology;Less than 250 employees;1,284 Number of companies carrying out R&D in Biotechnology;250 and more employees;160 Number of companies carrying out R&D in Biotechnology;Total;1,444 % Companies by type of biotechnology used: Genetic Code;Less than 250 employees;29.7 % Companies by type of biotechnology used: Genetic Code;250 and more employees;38.6 % Companies by type of biotechnology used: Genetic Code;Total;30.7 % Companies by type of biotechnology used: Functional Units;Less than 250 employees;36.6 % Companies by type of biotechnology used: Functional Units;250 and more employees;45.5 % Companies by type of biotechnology used: Functional Units;Total;37.6 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Less than 250 employees;20.0 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;250 and more employees;31.6 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Total;21.3 % Companies by type of biotechnology used: Bioprocesses;Less than 250 employees;49.5 % Companies by type of biotechnology used: Bioprocesses;250 and more employees;62.6 % Companies by type of biotechnology used: Bioprocesses;Total;50.9 % Companies by type of biotechnology used: Subcellular Organisms;Less than 250 employees;6.8 % Companies by type of biotechnology used: Subcellular Organisms;250 and more employees;18.3 % Companies by type of biotechnology used: Subcellular Organisms;Total;8.1 % Companies by type of biotechnology used: Bioinformatics;Less than 250 employees;22.1 % Companies by type of biotechnology used: Bioinformatics;250 and more employees;26.6 % Companies by type of biotechnology used: Bioinformatics;Total;22.6 % Companies by type of biotechnology used: Nanobiotechnology;Less than 250 employees;9.8 % Companies by type of biotechnology used: Nanobiotechnology;250 and more employees;10.2 % Companies by type of biotechnology used: Nanobiotechnology;Total;9.8 % Companies by type of biotechnology used: Other;Less than 250 employees;16.8 % Companies by type of biotechnology used: Other;250 and more employees;17.2 % Companies by type of biotechnology used: Other;Total;16.9 Companies in which biotechnology activities are: Main and/or exclusive;Less than 250 employees;604 Companies in which biotechnology activities are: Main and/or exclusive;250 and more employees;25 Companies in which biotechnology activities are: Main and/or exclusive;Total;629 Companies in which biotechnology activities are: A secondary business line;Less than 250 employees;215 Companies in which biotechnology activities are: A secondary business line;250 and more employees;47 Companies in which biotechnology activities are: A secondary business line;Total;262 Companies in which biotechnology activities are: A necessary tool for production;Less than 250 employees;465 Companies in which biotechnology activities are: A necessary tool for production;250 and more employees;88 Companies in which biotechnology activities are: A necessary tool for production;Total;553 % Companies by final application areas of biotechnology use: Human Health;Less than 250 employees;44.7 % Companies by final application areas of biotechnology use: Human Health;250 and more employees;41.1 % Companies by final application areas of biotechnology use: Human Health;Total;44.3 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Less than 250 employees;16.2 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;250 and more employees;12.1 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Total;15.8 % Companies by final application areas of biotechnology use: Food Products;Less than 250 employees;29.4 % Companies by final application areas of biotechnology use: Food Products;250 and more employees;41.1 % Companies by final application areas of biotechnology use: Food Products;Total;30.7 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Less than 250 employees;25.6 % Companies by final application areas of biotechnology use: Agriculture and Forestry;250 and more employees;20.1 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Total;24.9 % Companies by final application areas of biotechnology use: Environment;Less than 250 employees;17.3 % Companies by final application areas of biotechnology use: Environment;250 and more employees;13.9 % Companies by final application areas of biotechnology use: Environment;Total;16.9 % Companies by final application areas of biotechnology use: Industry;Less than 250 employees;12.5 % Companies by final application areas of biotechnology use: Industry;250 and more employees;13.3 % Companies by final application areas of biotechnology use: Industry;Total;12.6 R&D personnel in Biotechnology (PP);Less than 250 employees;10,452 R&D personnel in Biotechnology (PP);250 and more employees;7,291 R&D personnel in Biotechnology (PP);Total;17,743 R&D personnel in Biotechnology (PP): Research personnel;Less than 250 employees;6,309 R&D personnel in Biotechnology (PP): Research personnel;250 and more employees;3,136 R&D personnel in Biotechnology (PP): Research personnel;Total;9,445 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Less than 250 employees;4,144 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;250 and more employees;4,154 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Total;8,298 R&D personnel in Biotechnology (PP). Women;Less than 250 employees;5,369 R&D personnel in Biotechnology (PP). Women;250 and more employees;4,538 R&D personnel in Biotechnology (PP). Women;Total;9,907 R&D personnel in Biotechnology (PP). Women: Research personnel;Less than 250 employees;3,273 R&D personnel in Biotechnology (PP). Women: Research personnel;250 and more employees;1,832 R&D personnel in Biotechnology (PP). Women: Research personnel;Total;5,104 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Less than 250 employees;2,096 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;250 and more employees;2,707 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Total;4,802 R&D personnel in Biotechnology (FTE);Less than 250 employees;7,232.7 R&D personnel in Biotechnology (FTE);250 and more employees;5,760.8 R&D personnel in Biotechnology (FTE);Total;12,993.4 R&D personnel in Biotechnology (FTE): Research personnel;Less than 250 employees;4,671.5 R&D personnel in Biotechnology (FTE): Research personnel;250 and more employees;2,398.3 R&D personnel in Biotechnology (FTE): Research personnel;Total;7,069.9 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Less than 250 employees;2,561.2 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;250 and more employees;3,362.4 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Total;5,923.6 R&D personnel in Biotechnology (FTE). Women;Less than 250 employees;3,763.9 R&D personnel in Biotechnology (FTE). Women;250 and more employees;3,707.8 R&D personnel in Biotechnology (FTE). Women;Total;7,471.8 R&D personnel in Biotechnology (FTE). Women: Research personnel;Less than 250 employees;2,449.2 R&D personnel in Biotechnology (FTE). Women: Research personnel;250 and more employees;1,421.0 R&D personnel in Biotechnology (FTE). Women: Research personnel;Total;3,870.1 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Less than 250 employees;1,314.8 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;250 and more employees;2,286.9 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Total;3,601.6 Expenditure on internal R&D in Biotechnology (thousands of euros);Less than 250 employees;691,268 Expenditure on internal R&D in Biotechnology (thousands of euros);250 and more employees;532,533 Expenditure on internal R&D in Biotechnology (thousands of euros);Total;1,223,801 1) By type of expenditure: Current expenditure;Less than 250 employees;614,656 1) By type of expenditure: Current expenditure;250 and more employees;493,534 1) By type of expenditure: Current expenditure;Total;1,108,189 1.1) Labour expenditure of research personnel;Less than 250 employees;221,957 1.1) Labour expenditure of research personnel;250 and more employees;138,965 1.1) Labour expenditure of research personnel;Total;360,922 1.2) Labour expenditure of technical and auxiliary personnel;Less than 250 employees;96,161 1.2) Labour expenditure of technical and auxiliary personnel;250 and more employees;124,379 1.2) Labour expenditure of technical and auxiliary personnel;Total;220,540 1.3) Other current expenditure;Less than 250 employees;296,538 1.3) Other current expenditure;250 and more employees;230,190 1.3) Other current expenditure;Total;526,727 2) By type of expenditure: Capital expenditure;Less than 250 employees;76,612 2) By type of expenditure: Capital expenditure;250 and more employees;39,000 2) By type of expenditure: Capital expenditure;Total;115,612 2.1) Land and buildings;Less than 250 employees;7,247 2.1) Land and buildings;250 and more employees;9,596 2.1) Land and buildings;Total;16,843 2.2) Equipment and tools;Less than 250 employees;37,708 2.2) Equipment and tools;250 and more employees;25,819 2.2) Equipment and tools;Total;63,527 2.3) Acquisition of specific R&D software;Less than 250 employees;2,767 2.3) Acquisition of specific R&D software;250 and more employees;1,191 2.3) Acquisition of specific R&D software;Total;3,959 2.4) Other R&D-specific IP products;Less than 250 employees;28,890 2.4) Other R&D-specific IP products;250 and more employees;2,394 2.4) Other R&D-specific IP products;Total;31,284 1.1) By origin of funds: Own funds;Less than 250 employees;471,465 1.1) By origin of funds: Own funds;250 and more employees;389,138 1.1) By origin of funds: Own funds;Total;860,603 1.2) By origin of funds: Funds from the Business sector;Less than 250 employees;77,630 1.2) By origin of funds: Funds from the Business sector;250 and more employees;50,371 1.2) By origin of funds: Funds from the Business sector;Total;128,002 1.3) By origin of funds: Funds from the Public Administration sector;Less than 250 employees;96,976 1.3) By origin of funds: Funds from the Public Administration sector;250 and more employees;22,523 1.3) By origin of funds: Funds from the Public Administration sector;Total;119,498 1.4) By origin of funds: Funds from the Higher Education sector;Less than 250 employees;647 1.4) By origin of funds: Funds from the Higher Education sector;250 and more employees;0 1.4) By origin of funds: Funds from the Higher Education sector;Total;647 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Less than 250 employees;1,563 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;250 and more employees;11,423 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Total;12,986 1.6) By origin of funds: Funds from the rest of the world;Less than 250 employees;42,988 1.6) By origin of funds: Funds from the rest of the world;250 and more employees;59,078 1.6) By origin of funds: Funds from the rest of the world;Total;102,065 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Less than 250 employees;43,120 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);250 and more employees;80,276 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Total;123,396 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Less than 250 employees;22,993 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;250 and more employees;65,992 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Total;88,985 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Less than 250 employees;20,127 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;250 and more employees;14,284 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Total;34,412 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Less than 250 employees;41.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;250 and more employees;23.6 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Total;39.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Less than 250 employees;15.2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;250 and more employees;16.4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Total;15.3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Less than 250 employees;22.9 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;250 and more employees;17.3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Total;22.3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Less than 250 employees;11.5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;250 and more employees;17.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Total;12.1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Less than 250 employees;17.2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;250 and more employees;15.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Total;17.1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Less than 250 employees;18.1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;250 and more employees;15.3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Total;17.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Less than 250 employees;15.4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;250 and more employees;20.3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Total;16.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Less than 250 employees;41.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;250 and more employees;38.5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Total;41.4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Less than 250 employees;51.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;250 and more employees;44.2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Total;50.2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Less than 250 employees;20.7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;250 and more employees;15.1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Total;20.1 % Companies with international revenues related to biotechnology activities;Less than 250 employees;23.0 % Companies with international revenues related to biotechnology activities;250 and more employees;20.2 % Companies with international revenues related to biotechnology activities;Total;22.7 % Companies representing international revenues related to biotechnology activities;Less than 250 employees;8.2 % Companies representing international revenues related to biotechnology activities;250 and more employees;1.3 % Companies representing international revenues related to biotechnology activities;Total;2.1 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Less than 250 employees;55.4 % International revenues related to biotechnology activities distributed in: Revenues from the EU;250 and more employees;64.9 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Total;60.6 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Less than 250 employees;44.6 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;250 and more employees;35.1 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Total;39.4 % International revenues related to biotechnology activities by classification: International trade in goods and services;Less than 250 employees;93.9 % International revenues related to biotechnology activities by classification: International trade in goods and services;250 and more employees;82.8 % International revenues related to biotechnology activities by classification: International trade in goods and services;Total;87.8 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Less than 250 employees;3.8 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;250 and more employees;15.1 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Total;10.1 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Less than 250 employees;0.7 % International revenues related to biotechnology activities by classification: Subsidies from external sources;250 and more employees;2.0 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Total;1.4 % International revenues related to biotechnology activities by classification: Other;Less than 250 employees;1.7 % International revenues related to biotechnology activities by classification: Other;250 and more employees;0.0 % International revenues related to biotechnology activities by classification: Other;Total;0.8