Indicator type;Size of the company;Total Number of companies carrying out R&D in Biotechnology;Less than 250 employees;1.284 Number of companies carrying out R&D in Biotechnology;250 and more employees;160 Number of companies carrying out R&D in Biotechnology;Total;1.444 % Companies by type of biotechnology used: Genetic Code;Less than 250 employees;29,7 % Companies by type of biotechnology used: Genetic Code;250 and more employees;38,6 % Companies by type of biotechnology used: Genetic Code;Total;30,7 % Companies by type of biotechnology used: Functional Units;Less than 250 employees;36,6 % Companies by type of biotechnology used: Functional Units;250 and more employees;45,5 % Companies by type of biotechnology used: Functional Units;Total;37,6 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Less than 250 employees;20 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;250 and more employees;31,6 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Total;21,3 % Companies by type of biotechnology used: Bioprocesses;Less than 250 employees;49,5 % Companies by type of biotechnology used: Bioprocesses;250 and more employees;62,6 % Companies by type of biotechnology used: Bioprocesses;Total;50,9 % Companies by type of biotechnology used: Subcellular Organisms;Less than 250 employees;6,8 % Companies by type of biotechnology used: Subcellular Organisms;250 and more employees;18,3 % Companies by type of biotechnology used: Subcellular Organisms;Total;8,1 % Companies by type of biotechnology used: Bioinformatics;Less than 250 employees;22,1 % Companies by type of biotechnology used: Bioinformatics;250 and more employees;26,6 % Companies by type of biotechnology used: Bioinformatics;Total;22,6 % Companies by type of biotechnology used: Nanobiotechnology;Less than 250 employees;9,8 % Companies by type of biotechnology used: Nanobiotechnology;250 and more employees;10,2 % Companies by type of biotechnology used: Nanobiotechnology;Total;9,8 % Companies by type of biotechnology used: Other;Less than 250 employees;16,8 % Companies by type of biotechnology used: Other;250 and more employees;17,2 % Companies by type of biotechnology used: Other;Total;16,9 Companies in which biotechnology activities are: Main and/or exclusive;Less than 250 employees;604 Companies in which biotechnology activities are: Main and/or exclusive;250 and more employees;25 Companies in which biotechnology activities are: Main and/or exclusive;Total;629 Companies in which biotechnology activities are: A secondary business line;Less than 250 employees;215 Companies in which biotechnology activities are: A secondary business line;250 and more employees;47 Companies in which biotechnology activities are: A secondary business line;Total;262 Companies in which biotechnology activities are: A necessary tool for production;Less than 250 employees;465 Companies in which biotechnology activities are: A necessary tool for production;250 and more employees;88 Companies in which biotechnology activities are: A necessary tool for production;Total;553 % Companies by final application areas of biotechnology use: Human Health;Less than 250 employees;44,7 % Companies by final application areas of biotechnology use: Human Health;250 and more employees;41,1 % Companies by final application areas of biotechnology use: Human Health;Total;44,3 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Less than 250 employees;16,2 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;250 and more employees;12,1 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Total;15,8 % Companies by final application areas of biotechnology use: Food Products;Less than 250 employees;29,4 % Companies by final application areas of biotechnology use: Food Products;250 and more employees;41,1 % Companies by final application areas of biotechnology use: Food Products;Total;30,7 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Less than 250 employees;25,6 % Companies by final application areas of biotechnology use: Agriculture and Forestry;250 and more employees;20,1 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Total;24,9 % Companies by final application areas of biotechnology use: Environment;Less than 250 employees;17,3 % Companies by final application areas of biotechnology use: Environment;250 and more employees;13,9 % Companies by final application areas of biotechnology use: Environment;Total;16,9 % Companies by final application areas of biotechnology use: Industry;Less than 250 employees;12,5 % Companies by final application areas of biotechnology use: Industry;250 and more employees;13,3 % Companies by final application areas of biotechnology use: Industry;Total;12,6 R&D personnel in Biotechnology (PP);Less than 250 employees;10.452 R&D personnel in Biotechnology (PP);250 and more employees;7.291 R&D personnel in Biotechnology (PP);Total;17.743 R&D personnel in Biotechnology (PP): Research personnel;Less than 250 employees;6.309 R&D personnel in Biotechnology (PP): Research personnel;250 and more employees;3.136 R&D personnel in Biotechnology (PP): Research personnel;Total;9.445 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Less than 250 employees;4.144 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;250 and more employees;4.154 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Total;8.298 R&D personnel in Biotechnology (PP). Women;Less than 250 employees;5.369 R&D personnel in Biotechnology (PP). Women;250 and more employees;4.538 R&D personnel in Biotechnology (PP). Women;Total;9.907 R&D personnel in Biotechnology (PP). Women: Research personnel;Less than 250 employees;3.273 R&D personnel in Biotechnology (PP). Women: Research personnel;250 and more employees;1.832 R&D personnel in Biotechnology (PP). Women: Research personnel;Total;5.104 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Less than 250 employees;2.096 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;250 and more employees;2.707 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Total;4.802 R&D personnel in Biotechnology (FTE);Less than 250 employees;7.232,7 R&D personnel in Biotechnology (FTE);250 and more employees;5.760,8 R&D personnel in Biotechnology (FTE);Total;12.993,4 R&D personnel in Biotechnology (FTE): Research personnel;Less than 250 employees;4.671,5 R&D personnel in Biotechnology (FTE): Research personnel;250 and more employees;2.398,3 R&D personnel in Biotechnology (FTE): Research personnel;Total;7.069,9 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Less than 250 employees;2.561,2 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;250 and more employees;3.362,4 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Total;5.923,6 R&D personnel in Biotechnology (FTE). Women;Less than 250 employees;3.763,9 R&D personnel in Biotechnology (FTE). Women;250 and more employees;3.707,8 R&D personnel in Biotechnology (FTE). Women;Total;7.471,8 R&D personnel in Biotechnology (FTE). Women: Research personnel;Less than 250 employees;2.449,2 R&D personnel in Biotechnology (FTE). Women: Research personnel;250 and more employees;1.421 R&D personnel in Biotechnology (FTE). Women: Research personnel;Total;3.870,1 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Less than 250 employees;1.314,8 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;250 and more employees;2.286,9 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Total;3.601,6 Expenditure on internal R&D in Biotechnology (thousands of euros);Less than 250 employees;691.268 Expenditure on internal R&D in Biotechnology (thousands of euros);250 and more employees;532.533 Expenditure on internal R&D in Biotechnology (thousands of euros);Total;1.223.801 1) By type of expenditure: Current expenditure;Less than 250 employees;614.656 1) By type of expenditure: Current expenditure;250 and more employees;493.534 1) By type of expenditure: Current expenditure;Total;1.108.189 1.1) Labour expenditure of research personnel;Less than 250 employees;221.957 1.1) Labour expenditure of research personnel;250 and more employees;138.965 1.1) Labour expenditure of research personnel;Total;360.922 1.2) Labour expenditure of technical and auxiliary personnel;Less than 250 employees;96.161 1.2) Labour expenditure of technical and auxiliary personnel;250 and more employees;124.379 1.2) Labour expenditure of technical and auxiliary personnel;Total;220.540 1.3) Other current expenditure;Less than 250 employees;296.538 1.3) Other current expenditure;250 and more employees;230.190 1.3) Other current expenditure;Total;526.727 2) By type of expenditure: Capital expenditure;Less than 250 employees;76.612 2) By type of expenditure: Capital expenditure;250 and more employees;39.000 2) By type of expenditure: Capital expenditure;Total;115.612 2.1) Land and buildings;Less than 250 employees;7.247 2.1) Land and buildings;250 and more employees;9.596 2.1) Land and buildings;Total;16.843 2.2) Equipment and tools;Less than 250 employees;37.708 2.2) Equipment and tools;250 and more employees;25.819 2.2) Equipment and tools;Total;63.527 2.3) Acquisition of specific R&D software;Less than 250 employees;2.767 2.3) Acquisition of specific R&D software;250 and more employees;1.191 2.3) Acquisition of specific R&D software;Total;3.959 2.4) Other R&D-specific IP products;Less than 250 employees;28.890 2.4) Other R&D-specific IP products;250 and more employees;2.394 2.4) Other R&D-specific IP products;Total;31.284 1.1) By origin of funds: Own funds;Less than 250 employees;471.465 1.1) By origin of funds: Own funds;250 and more employees;389.138 1.1) By origin of funds: Own funds;Total;860.603 1.2) By origin of funds: Funds from the Business sector;Less than 250 employees;77.630 1.2) By origin of funds: Funds from the Business sector;250 and more employees;50.371 1.2) By origin of funds: Funds from the Business sector;Total;128.002 1.3) By origin of funds: Funds from the Public Administration sector;Less than 250 employees;96.976 1.3) By origin of funds: Funds from the Public Administration sector;250 and more employees;22.523 1.3) By origin of funds: Funds from the Public Administration sector;Total;119.498 1.4) By origin of funds: Funds from the Higher Education sector;Less than 250 employees;647 1.4) By origin of funds: Funds from the Higher Education sector;250 and more employees;0 1.4) By origin of funds: Funds from the Higher Education sector;Total;647 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Less than 250 employees;1.563 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;250 and more employees;11.423 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Total;12.986 1.6) By origin of funds: Funds from the rest of the world;Less than 250 employees;42.988 1.6) By origin of funds: Funds from the rest of the world;250 and more employees;59.078 1.6) By origin of funds: Funds from the rest of the world;Total;102.065 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Less than 250 employees;43.120 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);250 and more employees;80.276 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Total;123.396 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Less than 250 employees;22.993 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;250 and more employees;65.992 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Total;88.985 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Less than 250 employees;20.127 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;250 and more employees;14.284 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Total;34.412 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Less than 250 employees;41,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;250 and more employees;23,6 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Total;39,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Less than 250 employees;15,2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;250 and more employees;16,4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Total;15,3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Less than 250 employees;22,9 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;250 and more employees;17,3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Total;22,3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Less than 250 employees;11,5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;250 and more employees;17 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Total;12,1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Less than 250 employees;17,2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;250 and more employees;15,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Total;17,1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Less than 250 employees;18,1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;250 and more employees;15,3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Total;17,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Less than 250 employees;15,4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;250 and more employees;20,3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Total;16 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Less than 250 employees;41,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;250 and more employees;38,5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Total;41,4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Less than 250 employees;51 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;250 and more employees;44,2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Total;50,2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Less than 250 employees;20,7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;250 and more employees;15,1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Total;20,1 % Companies with international revenues related to biotechnology activities;Less than 250 employees;23 % Companies with international revenues related to biotechnology activities;250 and more employees;20,2 % Companies with international revenues related to biotechnology activities;Total;22,7 % Companies representing international revenues related to biotechnology activities;Less than 250 employees;8,2 % Companies representing international revenues related to biotechnology activities;250 and more employees;1,3 % Companies representing international revenues related to biotechnology activities;Total;2,1 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Less than 250 employees;55,4 % International revenues related to biotechnology activities distributed in: Revenues from the EU;250 and more employees;64,9 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Total;60,6 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Less than 250 employees;44,6 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;250 and more employees;35,1 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Total;39,4 % International revenues related to biotechnology activities by classification: International trade in goods and services;Less than 250 employees;93,9 % International revenues related to biotechnology activities by classification: International trade in goods and services;250 and more employees;82,8 % International revenues related to biotechnology activities by classification: International trade in goods and services;Total;87,8 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Less than 250 employees;3,8 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;250 and more employees;15,1 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Total;10,1 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Less than 250 employees;0,7 % International revenues related to biotechnology activities by classification: Subsidies from external sources;250 and more employees;2 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Total;1,4 % International revenues related to biotechnology activities by classification: Other;Less than 250 employees;1,7 % International revenues related to biotechnology activities by classification: Other;250 and more employees;0 % International revenues related to biotechnology activities by classification: Other;Total;0,8