Indicator type;Size of the company;Total Number of companies carrying out R&D in Biotechnology;Less than 250 employees;1,221 Number of companies carrying out R&D in Biotechnology;250 and more employees;156 Number of companies carrying out R&D in Biotechnology;Total;1,376 % Companies by type of biotechnology used: Genetic Code;Less than 250 employees;30.2 % Companies by type of biotechnology used: Genetic Code;250 and more employees;41.5 % Companies by type of biotechnology used: Genetic Code;Total;31.4 % Companies by type of biotechnology used: Functional Units;Less than 250 employees;42.4 % Companies by type of biotechnology used: Functional Units;250 and more employees;54.3 % Companies by type of biotechnology used: Functional Units;Total;43.7 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Less than 250 employees;21.2 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;250 and more employees;35.9 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Total;22.8 % Companies by type of biotechnology used: Bioprocesses;Less than 250 employees;46.1 % Companies by type of biotechnology used: Bioprocesses;250 and more employees;65.3 % Companies by type of biotechnology used: Bioprocesses;Total;48.3 % Companies by type of biotechnology used: Subcellular Organisms;Less than 250 employees;7.0 % Companies by type of biotechnology used: Subcellular Organisms;250 and more employees;14.6 % Companies by type of biotechnology used: Subcellular Organisms;Total;7.9 % Companies by type of biotechnology used: Bioinformatics;Less than 250 employees;26.5 % Companies by type of biotechnology used: Bioinformatics;250 and more employees;32.5 % Companies by type of biotechnology used: Bioinformatics;Total;27.1 % Companies by type of biotechnology used: Nanobiotechnology;Less than 250 employees;11.0 % Companies by type of biotechnology used: Nanobiotechnology;250 and more employees;13.4 % Companies by type of biotechnology used: Nanobiotechnology;Total;11.2 % Companies by type of biotechnology used: Other;Less than 250 employees;18.1 % Companies by type of biotechnology used: Other;250 and more employees;14.0 % Companies by type of biotechnology used: Other;Total;17.6 Companies in which biotechnology activities are: Main and/or exclusive;Less than 250 employees;686 Companies in which biotechnology activities are: Main and/or exclusive;250 and more employees;25 Companies in which biotechnology activities are: Main and/or exclusive;Total;711 Companies in which biotechnology activities are: A secondary business line;Less than 250 employees;214 Companies in which biotechnology activities are: A secondary business line;250 and more employees;55 Companies in which biotechnology activities are: A secondary business line;Total;270 Companies in which biotechnology activities are: A necessary tool for production;Less than 250 employees;320 Companies in which biotechnology activities are: A necessary tool for production;250 and more employees;75 Companies in which biotechnology activities are: A necessary tool for production;Total;395 % Companies by final application areas of biotechnology use: Human Health;Less than 250 employees;48.7 % Companies by final application areas of biotechnology use: Human Health;250 and more employees;42.7 % Companies by final application areas of biotechnology use: Human Health;Total;48.0 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Less than 250 employees;16.7 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;250 and more employees;17.9 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Total;16.9 % Companies by final application areas of biotechnology use: Food Products;Less than 250 employees;28.0 % Companies by final application areas of biotechnology use: Food Products;250 and more employees;40.1 % Companies by final application areas of biotechnology use: Food Products;Total;29.4 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Less than 250 employees;26.1 % Companies by final application areas of biotechnology use: Agriculture and Forestry;250 and more employees;22.6 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Total;25.7 % Companies by final application areas of biotechnology use: Environment;Less than 250 employees;17.9 % Companies by final application areas of biotechnology use: Environment;250 and more employees;18.9 % Companies by final application areas of biotechnology use: Environment;Total;18.0 % Companies by final application areas of biotechnology use: Industry;Less than 250 employees;12.6 % Companies by final application areas of biotechnology use: Industry;250 and more employees;16.5 % Companies by final application areas of biotechnology use: Industry;Total;13.0 R&D personnel in Biotechnology (PP);Less than 250 employees;10,421 R&D personnel in Biotechnology (PP);250 and more employees;6,836 R&D personnel in Biotechnology (PP);Total;17,257 R&D personnel in Biotechnology (PP): Research personnel;Less than 250 employees;6,087 R&D personnel in Biotechnology (PP): Research personnel;250 and more employees;3,108 R&D personnel in Biotechnology (PP): Research personnel;Total;9,195 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Less than 250 employees;4,333 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;250 and more employees;3,728 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Total;8,061 R&D personnel in Biotechnology (PP). Women;Less than 250 employees;5,700 R&D personnel in Biotechnology (PP). Women;250 and more employees;4,280 R&D personnel in Biotechnology (PP). Women;Total;9,980 R&D personnel in Biotechnology (PP). Women: Research personnel;Less than 250 employees;3,359 R&D personnel in Biotechnology (PP). Women: Research personnel;250 and more employees;1,863 R&D personnel in Biotechnology (PP). Women: Research personnel;Total;5,222 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Less than 250 employees;2,341 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;250 and more employees;2,417 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Total;4,758 R&D personnel in Biotechnology (FTE);Less than 250 employees;7,562.8 R&D personnel in Biotechnology (FTE);250 and more employees;5,320.6 R&D personnel in Biotechnology (FTE);Total;12,883.4 R&D personnel in Biotechnology (FTE): Research personnel;Less than 250 employees;4,665.3 R&D personnel in Biotechnology (FTE): Research personnel;250 and more employees;2,437.9 R&D personnel in Biotechnology (FTE): Research personnel;Total;7,103.2 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Less than 250 employees;2,897.4 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;250 and more employees;2,882.8 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Total;5,780.2 R&D personnel in Biotechnology (FTE). Women;Less than 250 employees;4,222.0 R&D personnel in Biotechnology (FTE). Women;250 and more employees;3,378.6 R&D personnel in Biotechnology (FTE). Women;Total;7,600.6 R&D personnel in Biotechnology (FTE). Women: Research personnel;Less than 250 employees;2,605.7 R&D personnel in Biotechnology (FTE). Women: Research personnel;250 and more employees;1,451.3 R&D personnel in Biotechnology (FTE). Women: Research personnel;Total;4,057.0 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Less than 250 employees;1,616.3 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;250 and more employees;1,927.3 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Total;3,543.7 Expenditure on internal R&D in Biotechnology (thousands of euros);Less than 250 employees;794,091 Expenditure on internal R&D in Biotechnology (thousands of euros);250 and more employees;489,255 Expenditure on internal R&D in Biotechnology (thousands of euros);Total;1,283,346 1) By type of expenditure: Current expenditure;Less than 250 employees;715,652 1) By type of expenditure: Current expenditure;250 and more employees;464,535 1) By type of expenditure: Current expenditure;Total;1,180,187 1.1) Labour expenditure of research personnel;Less than 250 employees;235,238 1.1) Labour expenditure of research personnel;250 and more employees;137,183 1.1) Labour expenditure of research personnel;Total;372,421 1.2) Labour expenditure of technical and auxiliary personnel;Less than 250 employees;113,075 1.2) Labour expenditure of technical and auxiliary personnel;250 and more employees;116,659 1.2) Labour expenditure of technical and auxiliary personnel;Total;229,734 1.3) Other current expenditure;Less than 250 employees;367,339 1.3) Other current expenditure;250 and more employees;210,693 1.3) Other current expenditure;Total;578,032 2) By type of expenditure: Capital expenditure;Less than 250 employees;78,439 2) By type of expenditure: Capital expenditure;250 and more employees;24,720 2) By type of expenditure: Capital expenditure;Total;103,159 2.1) Land and buildings;Less than 250 employees;8,547 2.1) Land and buildings;250 and more employees;2,342 2.1) Land and buildings;Total;10,889 2.2) Equipment and tools;Less than 250 employees;40,395 2.2) Equipment and tools;250 and more employees;18,809 2.2) Equipment and tools;Total;59,204 2.3) Acquisition of specific R&D software;Less than 250 employees;4,415 2.3) Acquisition of specific R&D software;250 and more employees;1,208 2.3) Acquisition of specific R&D software;Total;5,623 2.4) Other R&D-specific IP products;Less than 250 employees;25,082 2.4) Other R&D-specific IP products;250 and more employees;2,360 2.4) Other R&D-specific IP products;Total;27,442 1.1) By origin of funds: Own funds;Less than 250 employees;548,276 1.1) By origin of funds: Own funds;250 and more employees;339,251 1.1) By origin of funds: Own funds;Total;887,527 1.2) By origin of funds: Funds from the Business sector;Less than 250 employees;96,237 1.2) By origin of funds: Funds from the Business sector;250 and more employees;47,667 1.2) By origin of funds: Funds from the Business sector;Total;143,903 1.3) By origin of funds: Funds from the Public Administration sector;Less than 250 employees;98,923 1.3) By origin of funds: Funds from the Public Administration sector;250 and more employees;27,623 1.3) By origin of funds: Funds from the Public Administration sector;Total;126,546 1.4) By origin of funds: Funds from the Higher Education sector;Less than 250 employees;94 1.4) By origin of funds: Funds from the Higher Education sector;250 and more employees;0 1.4) By origin of funds: Funds from the Higher Education sector;Total;94 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Less than 250 employees;2,684 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;250 and more employees;9,939 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Total;12,623 1.6) By origin of funds: Funds from the rest of the world;Less than 250 employees;47,877 1.6) By origin of funds: Funds from the rest of the world;250 and more employees;64,776 1.6) By origin of funds: Funds from the rest of the world;Total;112,652 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Less than 250 employees;76,773 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);250 and more employees;60,659 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Total;137,432 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Less than 250 employees;38,607 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;250 and more employees;49,521 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Total;88,127 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Less than 250 employees;38,166 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;250 and more employees;11,139 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Total;49,305 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Less than 250 employees;46.3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;250 and more employees;23.2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Total;43.7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Less than 250 employees;16.3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;250 and more employees;15.5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Total;16.2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Less than 250 employees;24.6 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;250 and more employees;16.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Total;23.7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Less than 250 employees;14.4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;250 and more employees;14.5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Total;14.5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Less than 250 employees;19.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;250 and more employees;10.5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Total;18.1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Less than 250 employees;20.4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;250 and more employees;12.9 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Total;19.6 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Less than 250 employees;18.9 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;250 and more employees;21.2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Total;19.1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Less than 250 employees;51.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;250 and more employees;40.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Total;49.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Less than 250 employees;61.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;250 and more employees;46.8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Total;59.4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Less than 250 employees;23.7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;250 and more employees;11.0 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Total;22.3 % Companies with international revenues related to biotechnology activities;Less than 250 employees;23.6 % Companies with international revenues related to biotechnology activities;250 and more employees;22.7 % Companies with international revenues related to biotechnology activities;Total;23.6 % Companies representing international revenues related to biotechnology activities;Less than 250 employees;6.9 % Companies representing international revenues related to biotechnology activities;250 and more employees;1.0 % Companies representing international revenues related to biotechnology activities;Total;1.5 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Less than 250 employees;50.0 % International revenues related to biotechnology activities distributed in: Revenues from the EU;250 and more employees;62.8 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Total;57.6 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Less than 250 employees;50.0 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;250 and more employees;37.2 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Total;42.4 % International revenues related to biotechnology activities by classification: International trade in goods and services;Less than 250 employees;91.4 % International revenues related to biotechnology activities by classification: International trade in goods and services;250 and more employees;76.2 % International revenues related to biotechnology activities by classification: International trade in goods and services;Total;82.3 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Less than 250 employees;4.5 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;250 and more employees;20.6 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Total;14.1 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Less than 250 employees;1.0 % International revenues related to biotechnology activities by classification: Subsidies from external sources;250 and more employees;1.8 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Total;1.5 % International revenues related to biotechnology activities by classification: Other;Less than 250 employees;3.1 % International revenues related to biotechnology activities by classification: Other;250 and more employees;1.4 % International revenues related to biotechnology activities by classification: Other;Total;2.1